He explored La Plata, Paraguay and Parana river regions and founded Asuncion in 1537, moving the colony’s administration there from Buenos Aires.
He served as governor of the Spanish colonies from 1538 to 1540. Cabaza de Vaca was later appointed governor of the region, but Martinez de Irala revolted against his leadership, imprisoned de Vaca and had him deported back to Spain. Martinez de Irala then resumed the role of Governor of the Spanish colonies from 1544 until 1548.
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